Take a photo of Sander Cohen’s dead body for the “Irony” Achievement.
Get Free Health Packs
While you can buy health packs at health stations for $10, you can get them for free by simply smashing the machines with your wrench. After a few hits, between 1-3 health packs should lie on the floor for you to grab, for free.
Make Big Daddy Battle
In order to do this, you need the Hypnotize Big Daddy Plasmid and the Natural Camouflage Tonic. All you have to do is use the Hypnotize Big Daddy Plasmid on a Big Daddy so that he thinks you’re a Little Sister and protects you. Now here’s the fun part – simply find and attack another Big Daddy and your Big Daddy will attack it to protect you.
How to Get the Good Ending / Bad Ending
There are two possible endings for BioShock that depend on how you treated little sisters throughout the game. If you choose to “harvest” more than one little sister, you will get the bad BioShock ending. If, however, you “harvest” no more than one little sister but “rescue” the others, you will get the good BioShock ending.
Big Daddy Kills Tips and Tricks
When fighting a Big Daddy, use armor-piercing rounds, as they will deal considerable damage compared to regular rounds.
Big Daddy Kills V
If you have Trap Bolts for your Crossbow, you can execute this technique to kill Big Daddies easily. Give yourself about 20 feet (in-game, of course) and shoot your Trap Bolts so they hang between you and the location of the Big Daddy you want to kill. Then shoot a round with another weapon at the Big Daddy to anger it so it comes towards you. It will stumble across the Trap Bolts you’ve shot and die, since it only takes two of them to take one down.
Big Daddy Kills II
Once you get the Grenade Launcher and the Proximity Mines, this technique can be employed. Find a red fuel tank (all over the place), and cover it with about 6 Proximity Mines or so. Next, use Telekinesis to lift the massive explosive device and hurl it at a Big Daddy. This deals massive damage, leaving you with minimal effort to finish the job. Just be careful not to have the bomb blow up before you get there. (The launcher upgrade that deals no damage to you is a great thing to have just in case.)
Big Daddy Kills IV
Once you’ve obtained the Dart Gun, you can try this technique. All that’s required is Electrical Trap Darts (4-6 per Big Daddy). Take your 4-6 Trap Darts and line them down a hall or near where you can see a Big Daddy, making sure the path he’ll take towards you is amply covered. Once that’s done, shoot at the Big Daddy to get his attention and keep him running towards you. He’ll run into each dart and kill himself.
Big Daddy Kills III
Here’s another technique to take out Big Daddies. Use the Electric Buck on your Shotgun, alternating between the buck and using the Electro Bolt Plasmid every few seconds (which will shock and freeze him in addition to dealing damage). This technique is especially useful on Bouncer class Big Daddies.
Big Daddy Kills VI
Here’s another easy method to kill Big Daddies easily. Try using Electric Gel in the Chemical Thrower. It takes about 3/4 of a tank, but the Big Daddy won’t be able to move as you shoot and kill him.
Easy Splicer Kills
For easy Splicer kills, simply use Telekinesis on one to hurl its body at others in the vicinity. This method usually results in a one-hit kill and is especially useful against higher-level Splicers.
Power to the People Station Locations (Weapon Upgrades!)
Listed below are all twelve Power to the People stations, which can be used to garner weapon upgrades.
Sander Cohen (Missable Achievement Warning)
About halfway through the game, you meet Sander Cohen, this crazy artist dude. When you finish the level, you can just leave him or kill him. If you kill him at that point, you can’t get one of the Achievements “Find Cohen’s Room.” A while later you will stumble onto Cohen’s apartment. If he’s alive, two Splicers will be dancing in the main room, with Cohen watching from his locked private room. Kill the Splicers and then Cohen comes out to fight you, thus unlocking the door and allowing you to earn the Achievement.
Do Quick Reloads
The following works with both the Crossbow and the Grenade Launcher. While shooting either, you can rapidly reload by pressing the left trigger, then quickly after pressing the right trigger. This will allow you to start shooting without having to wait longer (several seconds) for your weapon to reload. This is especially useful against powerful enemies like Big Daddies.
Telekinesis Item Drops Make It Easier to Relocate What You Need
While using the Telekinesis Plasmid, you can drop the item you are holding instead of throwing it across the room. To do this you must have an item currently being held. Pick up any item, with the Telekinesis Plasmid selected. Using the LT button, keep holding the item, and don’t let go of the LT button.
When you’re ready to drop the item, press the RB button to open your weapons menu, and in the transition of the weapons menu opening, let go of the LT button. Choose your weapon and the item will drop safely to your feet. If done correctly, the item falls at your feet, instead of being thrown, which makes the item easier to find when you need it.
Added by SyrionSyronimus: A simpler way to drop the item you’re holding is to just hit ‘X’. So, with the Telekinesis Plasmid armed, hold LT to TK something to you. While it’s ‘in your face’, press X to drop it on the ground. No need to switch to weapons.
Manipulate the Security Drones
Use a blast of the Electric Shock Plasmid to temporarily disable security drones before you do anything else in a room. Then, run up to them within five seconds and hack them! You can hack while the game is on virtual “pause.” You’ll have security drones on your side for the rest of the time you are in a fight after doing this.